Platelet Rich Fibrin (PRF)

PRF is a natural biomaterial derived from fibrin, which does not require anticoagulants or artificial additives (biomedical modifiers). This enables the production of autologous fibrin membranes and plugs containing a high concentration of platelets and white cells. These components release growth factors at the surgical site for a period of seven to 14 days, thereby accelerating the natural healing process.

The fibrin is a reservoir of platelets that will slowly release growth factors and cytokines, which are the key factors for regeneration of the bone and maturation of the soft tissue. Platelet-rich fibrin (PRF) is an autologous platelet concentrate prepared from the patient’s own blood at the dentist’s office just before the oral/dental procedure.

Existing literature suggests that PRF plays a crucial role in promoting regeneration and tissue engineering in various oral surgery procedures. The slow polymerization process during centrifugation and the fibrin-based structure of PRF may contribute to its superiority as a healing biomaterial compared to PRP and other fibrin adhesives. 

Advantages of PRF as compared wtih PRP:

  • No anticoagulants that affect the release of growth factors.
  • No drugs (calcium chloride) that could affect fibrin polymerization.
  • No animal products (Bovine thrombin) that could affect the coagulation process and immune system activation.
  • PRF has the presence of natural fibrin network, which protects the growth factors from proteolysis.
  • PRF favors the development of micro vascularization leading to a more efficient cell migration.
  • PRF has the presence of monocytes, leukocytes and other white cells that have an important role during the inflammatory phase of healing.
  • PRF manufacturing requires minimum time from the doctor.



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